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M9490454.TXT
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1994-09-19
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Document 0454
DOCN M9490454
TI Serum immunoglobulin profiles in asymptomatic HIV-1 seropositive adults
and in patients with AIDS in Dar es Salaam, Tanzania.
DT 9411
AU Lyamuya EF; Maselle SY; Matre R; Department of Microbiology and
Immunology, Muhimbili University; College of Health Sciences, Dar es
Salaam, Tanzania.
SO East Afr Med J. 1994 Jan;71(1):24-8. Unique Identifier : AIDSLINE
MED/94333129
AB Serum levels of immunoglobulin classes and IgG subclasses were
determined in healthy seronegative (n = 50) and in HIV-1 seropositive
adults (n = 50) from Tanzania, a region with heterosexual HIV-1
transmission pattern. The mean levels of total IgG, IgG1, IgG3, IgA,
IgM, and IgD obtained were found to be significantly higher in HIV-1
seropositive sera than in control sera. The mean IgA, IgM, IgD and IgG3
levels showed an increasing trend with progression from asymptomatic
phase to AIDS phase. The mean levels for total IgG, IgG1 and IgG2
remained constant while that for IgG4 decreased with progression to AIDS
phase. From the findings, it is concluded that polyisotypic
hypergammaglobulinaemia and serum IgG subclass changes occur in HIV-1
seropositive individuals in Tanzania. The characteristic changes
observed for IgD, IgG3 and IgG4 levels with evolution from asymptomatic
to AIDS phases could be of value in monitoring disease progression.
DE Acquired Immunodeficiency Syndrome/*BLOOD/COMPLICATIONS/
EPIDEMIOLOGY/TRANSMISSION Adult Case-Control Studies Human
Hypergammaglobulinemia/ETIOLOGY HIV
Seropositivity/*BLOOD/COMPLICATIONS/EPIDEMIOLOGY/TRANSMISSION *HIV-1
Immunoglobulin Isotypes/*BLOOD/CLASSIFICATION Matched-Pair Analysis
*Population Surveillance Seroepidemiologic Methods Sex Behavior
Support, Non-U.S. Gov't Tanzania/EPIDEMIOLOGY Urban Population
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).